Formulation of Enalapril-Loaded Microspheres Using Emulsion Solvent Evaporation Technique for Bitter Taste Masking

The aim of the present study was to formulate polymer microspheres using emulsion solvent evaporation technique as an approach mask bitter taste enalapril maleate. Five models were prepared with two water-insoluble polymers. Talc used stabilize particle structure. Production yields ranged from 38 % 53 %; drug loading varied between 17 and 40 mean size 140 μm 339 μm. No interaction polymers estimated. A release in artificial saliva indicated a negligible amount dissolved test medium which demonstrated successful masking.